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艾美捷科技代理Schircks Laboratories品牌。

瑞士Schircks Laboratories由B.Schircks博士于1980年创立,主要生产蝶啶及蝶啶类化合物(Pteridines)。至今,Schircks实验室合成了100多种蝶啶类化合物,主要用于科学研究和临床诊断应用。产品包括:

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11.1806-(L-1,2,3-Trihydroxybutyl)-pterin [Rhamnopterin]
11.182(6R,S)-5,6,7,8-Tetrahydro-L-rhamnopterin dihydrochloride
11.203L-Biopterin [L-erythro-Biopterin] 
11.2067,8-Dihydro-L-biopterin
11.209(6R,S)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride 
11.212(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
11.213(6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride
11.215(6S)-5,6,7,8-Tetrahydro-L-biopterin sulfate
11.216(6S)-5,6,7,8-Tetrahydro-L-biopterin sulfate
11.217(6R)-5-Methyl-5,6,7,8-tetrahydro-L-biopterin dihydrochloride
11.218D-Biopterin [D-erythro-Biopterin]
11.220(6R,S)-5,6,7,8-Tetrahydro-D-biopterin dihydrochloride
11.221D-threo-Biopterin [Dictyopterin] 
11.223(6R,S)-5,6,7,8-Tetrahydro-D-threo-biopterin dihydrochloride 
11.228Deoxysepiapterin
11.2296-((1R,S)-Hydroxypropyl)pterin [(1'R,S)-2'-Deoxybiopterin]
11.2317-Biopterin 
11.2347-Tetrahydro-L-biopterin dihydrochloride
11.260Oncopterin
11.2704-Hydroxy-6-(L-erythro-1,2-dihydroxy-propyl)-2-(methylthio)pteridine
11.2804-Amino-L-biopterin [2,4-Diamino-6-(L-erythro-1',2'-dihydroxypropyl)pteridine]
11.2824-Amino-(6R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride
11.2834-Amino-(6R)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride
11.303D-Neopterin [D-erythro-Neopterin] 
11.3067,8-Dihydro-D-neopterin  
11.3077,8-Dihydro-D-neopterin-3’-triphosphate  (Please refer to our reference 8)
11.309(6R,S)-5,6,7,8-Tetrahydro-D-neopterin dihydrochloride
11.314D-Neopterin-3’-monophosphate, lithium salt
11.3157,8-Dihydro-D-neopterin-3’-monophosphate, lithium salt  
11.3203'-Hydroxy-D-sepiapterin
11.3307-Neopterin  
11.340L-Monapterin [L-threo-Neopterin]
11.3457,8-Dihydro-L-monapterin
11.346(6R,S)-5,6,7,8-Tetrahydro-L-monapterin dihydrochloride
11.349D-Monapterin [D-threo-Neopterin]
11.403Pterin-6-carboxylic acid
11.409Pterin-7-carboxylic acid
11.4156-Formylpterin [Pterin-6-aldehyde]
11.4166-Formyl-7,8-dihydropterin
11.418Acetyl-6-formylpterin
11.4206-Hydroxymethylpterin
11.4216-Hydroxymethyl-7,8-dihydropterin hydrochloride
11.4226-Hydroxymethyl-7,8-dihydropterin-diphosphate    (Please refer to our reference 8)
11.423(6R,S)-6-Hydroxymethyl-5,6,7,8-tetrahydropterin dihydrochloride
11.4296-Hydroxymethylpterin-monophosphate 
11.4386-Hydroxymethylpterin-diphosphate, lithium salt  
11.4806-Methylpterin
11.4816-Methyl-7,8-dihydropterin hydrochloride
11.483(6R,S)-6-Methyl-5,6,7,8-tetrahydropterin dihydrochloride
11.5036,7-Dimethylpterin
11.5066,7-Dimethyl-7,8-dihydropterin monohydrochloride
11.5096,7-Dimethyl-5,6,7,8-tetrahydropterin monohydrochloride
11.703Leucopterin
11.713Xanthopterin
11.716Dihydroxanthopterin
11.723Isoxanthopterin
11.903Pterin
11.9067,8-Dihydropterin  (Please refer to our reference 20)
11.9095,6,7,8-Tetrahydropterin dihydrochloride
13.103Lumazine
13.2036-Hydroxylumazine
13.2066-Hydroxy-7,8-dihydrolumazine
13.2207-Hydroxylumazine
16.113Pteroic acid
16.123N10-(Trifluoroacetyl)pteroic acid
16.14010-Formylpteroic acid
16.203Folic acid  
16.2067,8-Dihydrofolic acid
16.208(6S)-5,6,7,8-Tetrahydrofolic acid trihydrochloride  
16.209(6R,S)-5,6,7,8-Tetrahydrofolic acid trihydrochloride 
16.21110-Methylfolic acid
16.21510-Formylfolic acid  
16.21710-Formyl-5,6,7,8-tetrahydrofolic acid  (Please refer to our reference 19)
16.220(6R,S)-5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt 
16.222(6R)-5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt (unnatural calcium folinate)  
16.230(6R,S)-5,10-Methenyl-5,6,7,8-tetrahydrofolic acid chloride
16.233(6R,S)-5-Methyl-5,6-dihydrofolic acid, ammonium salt  
16.235(6R,S)-5-Methyl-5,6,7,8-tetrahydrofolic acid, calcium salt
16.236(6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid, calcium salt
16.243(6R,S)-5-Methyl-5,6,7,8-tetrahydropteroyltri-γ-L-glutamic acid trihydrochloride
16.244(6R,S)-5-Methyl-5,6,7,8-tetrahydropteroyltetra-γ-L-glutamic acid trihydrochloride
16.252Pteroyldi-γ-L-glutamic acid  
16.253Pteroyltri-γ-L-glutamic acid   has been discontinued
16.254Pteroyltetra-γ-L-glutamic acid  
16.255Pteroylpenta-γ-L-glutamic acid  has been discontinued
16.266Pteroylhexa-γ-L-glutamic acid, ammonium salt
16.267Pteroylhepta-γ-L-glutamic acid, ammonium salt  
16.280(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroic acid
16.282(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroyldi-γ-L-glutamic acid, lithium salt has been discontinued
16.283(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroyltri-γ-L-glutamic acid, lithium salt has been discontinued
16.284(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroyltetra-γ-L-glutamic acid, lithium salt
16.285(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroylpenta-γ-L-glutamic acid, lithium salt
16.286(6R,S)-5-Formyl-5,6,7,8-tetrahydropteroylhexa-γ-L-glutamic acid, lithium salt
16.330Aminopterin [4-Aminofolic acid]
16.4034-Amino-10-methylpteroic acid (APA, DAMPA)
16.411Methotrexate  [4-Amino-10-methylpteroyl-γ-L-glutamic acid]
16.4124-Amino-10-methylpteroyldi-γ-L-glutamic acid, ammonium salt [Methotrexate diglutamate]
16.4134-Amino-10-methylpteroyltri-γ-L-glutamic acid, ammonium salt [Methotrexate triglutamate] 
16.4144-Amino-10-methylpteroyltetra-γ-L-glutamic acid, ammonium salt [Methotrexate tetraglutamate] 
16.4154-Amino-10-methylpteroylpenta-γ-L-glutamic acid, ammonium salt [Methotrexate pentaglutamate]
16.4164-Amino-10-methylpteroylhexa-γ-L-glutamic acid, ammonium salt [Methotrexate hexaglutamate]
16.4174-Amino-10-methylpteroylhepta-γ-L-glutamic acid, ammonium salt [Methotrexate heptaglutamate] 
16.5007-Hydroxymethotrexate   
16.701p-Aminobenzoyl-L-glutamic acid
16.702p-Aminobenzoyldi-γ-L-glutamic acid, ammonium salt  
16.703p-Aminobenzoyltri-γ-L-glutamic acid, ammonium salt  
16.704p-Aminobenzoyltetra-γ-L-glutamic acid, ammonium salt  
16.705p-Aminobenzoylpenta-γ-L-glutamic acid, ammonium salt  
16.706p-Aminobenzoylhexa-γ-L-glutamic acid,  ammonium salt 
16.707p-Aminobenzoylhepta-γ-L-glutamic acid, ammonium salt  has been discontinued
16.901Z-Glu-OtBu
16.902Z-Glu2-OtBu3
16.903Z-Glu3-OtBu4  
16.904Z-Glu4-OtBu5  
16.905Z-Glu5-OtBu6  
16.906Z-Glu6-OtBu7  
91.303D-(5-15N)-Neopterin
96.203(5-15N)-Folic acid 
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艾美捷科技代理Gene Tools品牌


Gene Tools是一家生产和销售Morpholino Anti-sense oligos(反义寡核苷酸)的公司,其产品专门用于基因调控的科学研究和药物开发。Gene Tools公司由多位资深科学家组成,为全球客户提供免费的技术咨询和Morpholino 序列设计服务。 Morpholino作为基因调控研究的最佳工具,已被广泛用于:阻断靶mRNA 翻译 (下调基因);诱导RNA选择性剪接 (下调或上调基因);阻断 miRNA;阻断病毒 RNA;阻断 non-coding RNA。


Morpholino介绍

Morpholino属于第三代反义寡核苷酸,主要通过阻断蛋白质翻译过程而达到抑制目标基因功能的作用,目前已经广泛用于发育生物学和细胞学实验中,并取得了非常好的实验效果。

Morpholino以吗啉环类似物为基本骨架,这种独特的结构特性使得Morpholino 具有以下几个特点:

● 与其他类型的反义寡核苷酸相比,Morpholino 能更好地抵抗核酸酶的作用;

● Morpholino 与靶序列结合后通过空间位阻效应发挥作用, 不激活RNaseH,不引起目标基因mRNA 的降解 ;

● 针对翻译起始位点区设计的Morpholino 用于抑制蛋白质的翻译,针对 pre-mRNA 剪切位点区设计的Morpholino 可影响mRNA 剪切,得到不 同的转录本,可以方便地用于目标基因结构域的突变研究;

● 与靶序列结合能力强,可以渗入mRNA 的二级结构, 并且特异性好。

配合Morpholino 的使用,Gene Tools公司开发了相应的递送系统,可以安全、高效地将Morpholino 输送至胞内,因此,Morpholino 也可以用于遗传学研究和新药靶标的发现以及验证。此外,Morpholino 可以标上荧光基团、亲和标签以及活性反应基团,以供不同的研究需要。

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Gene Tools公司产品介绍

● Custom Morpholino:可以根据目标基因序列定制设计并合成Morpholino,用于体外细胞实验或某些直接显微注射的模型(如斑马鱼、非洲爪蟾胚胎)。

● Vivo-Morpholino:适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。通过特殊的末端修饰,提高了其穿透细胞膜进入组织细胞的能力,使得在成年动物(主要是小鼠、大鼠)中进行系统性基因功能研究成为可能。

● Prepared Control Oligos:根据特定需求合成细胞穿透肽偶联的 Morpholino。适用于活体动物模型(小鼠,大鼠,狗,灵长类等),细胞培养,器官培养等。


产品名称Short DescriptionOligo sequenceSKU
Standard Control Oligo Negative control oligoCCTCTTACCTCAGTTACAATTTATAPCO-StandardControl-100
Vivo-Morpholino Standard Control OligoNegative Vivo-Morpholino control oligoCCTCTTACCTCAGTTACAATTTATAPCO-VivoStandardControl-100
Random Control Oligo 25-N25-base random sequence mixtureNNNNNNNNNNNNNNNNNNNNNNNNNPCO-RandomControl-25N-100
Zebrafish p53 oligoDanio rerio apoptosis suppression oligoGCGCCATTGCTTTGCAAGAATTGPCO-ZebrafishP53-100
Zebrafish Chordin Positive Control OligoDanio rerio Chordin positive control oligoATCCACAGCAGCCCCTCCATCATCCPCO-ZebrafishChordin-100-F
Clawed Frog Beta Catenin Positive Control OligoXenopus laevis Beta Catenin antisense oligoTTTCAACCGTTTCCAAAGAACCAGGPCO-BetaCatenin-100-F
Green Fluorescent Protein Positive ControlTranslation blocker for GFP targetACAGCTCCTCGCCCTTGCTCACCATPCO-GFPControl-100
Vivo-Morpholino GFP Positive ControlTranslation blocker for GFP target (Vivo-Morpholino)ACAGCTCCTCGCCCTTGCTCACCATPCO-VivoGFPControl-100
Fluoresceinated Vivo-Morpholino Std ControlNegative Vivo-Morpholino control oligo with 5'FluoresceinCCTCTTACCTCAGTTACAATTTATAPCO-FluorVivoStandardControl-100-F


● Endo-Porter:为了解决Morpholino在体外培养细胞中摄取效率低的问题,Gene Tools 开发了 Endo-Porter 这种特殊的转染试剂。它通过温和的内吞体逃逸机制帮助Morpholino进入细胞质。



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艾美捷科技代理AxisPharm品牌全系列产品


AxisPharm是一家专业的分析服务提供商,致力于为科学研究界和工业界提供高质量的分析服务。凭借先进的仪器设备和专业的技术团队,AxisPharm在生物分析、化学分析和质量控制领域树立了良好的声誉。AxisPharm公司的产品线包括:PEG 连接子、用于药物递送的脂质、荧光染料、单击化学试剂、聚聚乙二醇,共聚物、可裂解的连接子、抗体和抗体药物偶联物ADC、ADC 有效载荷、细胞生物学试剂、脱氧核糖核酸、修饰语、探针、合成肽、目标特定链接器、硫醇反应性接头、酸反应性连接子、胺反应性连接子、羰基反应性连接子、探针、修饰符。


AxisPharm页面.png


AxisPharm产品线

PEG连接子:聚合物聚乙二醇是多分散聚乙二醇 (PEG) 聚合物,是一种从石油中提取的聚醚化合物,具有从工业制造到医药的许多应用。

● 用于药物递送的脂质:在药物递送系统中起着至关重要的作用,特别是在脂质体、脂质纳米颗粒或脂质胶束等脂质制剂中。脂质提供结构稳定性,增强药物溶解度,实现控释,并促进靶向药物递送。

● 荧光染料:也称为荧光团或荧光探针,是吸收一种波长的光并以更高波长发射的化合物,从而产生可见荧光。它们是生物学研究中的重要工具,用于标记和检测蛋白质、核酸和细胞等生物分子,从而在显微镜、流式细胞术和实时荧光定量 PCR 等应用中实现灵敏和精确的可视化。

● 点击化学试剂:具有高特异性和最少的副产物,简化了复杂的合成过程。因此,它们在分子生物学、材料科学和药物化学中发挥着至关重要的作用。

● 聚合物聚乙二醇:多分散聚乙二醇 (PEG) 聚合物,是一种从石油中提取的聚醚化合物,具有从工业制造到医药的许多应用。

● 可裂解连接子:一类重要的分子,广泛应用于药物发现、化学生物学和材料科学等各个领域。这些连接子充当两个或多个分子实体之间的连接桥,可以在特定条件下选择性地裂解,从而释放附着的分子。这一特性使它们成为生物活性化合物靶向药物递送、成像和控释的有吸引力的工具。

● 抗体及抗体-药物偶联物及细胞生物学试剂种类丰富可选择。

● ADC有效载荷:作为 ADC 的三个主要成分之一,有效载荷是高活性和有毒的药物分子,通过化学连接子附着在抗体上。有效载荷可以是小分子、蛋白质毒素、生物活性肽、酶,甚至放射性核素。通过适当的接头与适当的载体系统耦合的有效载荷可能会显示出靶向药物递送的特异性和有效性的提高。

● 脱氧核糖核酸:DNA 是脱氧核糖核酸的缩写,是一种包含所有生物体发育和功能的遗传指令的分子。DNA 由四个基本组成部分组成,称为核苷酸,由糖、磷酸基团和含氮碱基组成。

● 改性剂:改变其他分子或材料特性的化合物。在药物研发领域,改性剂在新型药物递送系统和生物医学设备的设计和优化中发挥着至关重要的作用。一种常见的改性剂类型是官能团,它是赋予分子特定化学和物理性质的原子的特定排列。

● 探针:AxisPharm 提供各种靶标特异性探针,例如叶酸 PEG、生物素 PEG、PROTAC PEG、荧光染料探针和图像探针。探针是一类含有官能团的化合物,旨在选择性地与生物分子(如酶、受体和核酸)相互作用。这些官能团包括荧光染料、生物素和亲和标签等,可以检测和定量复杂生物系统中的特定分子。


Different Types of Polyethylene Glycol PEG Linkers in Stock
Acid PEGDiketone PEGNon-PEG linkerPFP ester PEGSugar PEG β-Glucuronide Linker
Aldehyde PEGDNP PEGPEG-t-butyl esterPhosphonate PEGSulfonic acid PEG
Alkyne PEGDBCO PEGPEG-X-PEGPolymer PEGTCO PEG
Amino PEGDSPE PEGPeptide LinkersPropargyl PEGTetrazine PEG
Aminooxy PEGFluorescent PEGLipid PEGPROTAC LinkerHomobifunctional PEG
Azide PEGFmoc PEGM-PEGSilane PEGBromo PEG
BCN-PEGFolate PEGMaleimide PEGSPDP PEGTosylate PEG
Benzyl-PEGThiol PEGMeNH-PEGBranched PEGBis-Sulfone PEG
Biotin PEGHydrazide PEGNHS ester PEGHyNic PEGDOTA Reagent DOTA PEG
Bis-PEG-acidHydroxy PEGBoc-PEGBis-PEG-NHSIodo PEG
Bis-PEG-NHSCleavable Linkers


Lipids for Drug Delivery
Biotinyl Cap PEDodecanyl PEOther LipidPhosphatidylcholinePhosphatidylethanolamine
Biotinyl PEGlutaryl PEPDP PEPhosphoglycerolPtd Thioethanol
Caproylamine PEIonizable LipidPE MCCPhosphoserineSuccinyl PE
Cationic LipidLipid PEGCyanur PEMPB PE
Fluorescent Dye
AF DyesCyanine DyesMB DyesRhodamine DyeRox (carboxy-X-rhodamine) Dye
APDye FluorsDNP PEGJOER6GPeptide Labeling Reagents
Bodipy ProbesFluorescein (FAM)Pyrene ProbesTAMRA DyeClassic Fluorescent Dyes
IR FluorsQuenchersCoumarin 343

Click Chemistry Tools & Reagents
Alkyne PEGBCN-PEGPTAD LinkerTetrazine PEGClick Chemistry Auxiliary Reagents
Azide PEGDBCO PEGTCO PEGMethylcyclopropene Linkers
Polymer PEG
AcrylateBiotinFmocLipoamideSilane
Active esterBocFolateMaleimideStearic acid
AldehydeCarboxylic acidguanlian1010MW 2000TCO
AmineCholesterolHydrazideMW 5000Thiol
AzideDBCOHydroxylPolysarcosine
Cleavable Linkers
-S-S-CleavablePC CleavableDisulfide LinkersDde Cleavable Linkersβ-Glucuronide Linkers
Cleavable Peptidediazo biotin probesDTSSP crosslinkerPhotocleavable Biotin
Antibody and Antibody Drug Conjugate (ADC)
InotuzumabTrastuzumabEnfortumabLabetuzumab govitecanMirvetuximab soravtansine (solution)
VobramitamabDisitamabMirzotamabLoncastuximab tesirineTrastuzumab deruxtecan (solution)
PolatuzumabOzuriftamabBrentuximabTrastuzumab deruxtecanADC Control Human IgG1-Deruxtecan (DAR 8)
GemtuzumabInebilizumabDatopotamabCofetuzumab pelidotinGlembatumumab vedotin
Daratumumab (PBS)DenintuzumabSacituzumab govitecanBelantamab mafodotinTrastuzumab duocarmazine
PraluzatamabNaratuximabTisotumabEnfortumab vedotin-ejfvTrastuzumab emtansine (solution)
LorvotuzumabRolinsatamabTrastuzumab emtansineTelisotuzumab vedotinEnfortumab vedotin-ejfv (solution)
IzeltabartMipasetamabDatopotamab deruxtecanGemtuzumab ozogamicinBrentuximab vedotin (solution)
LupartumabIladatuzumabORM-5029Cantuzumab ravtansineDepatuxizumab mafodotin
CantuzumabBriobaceptIfinatamab deruxtecanTusamitamab ravtansineADC Control Human IgG1-Deruxtecan (DAR 4)
LonigutamabTamrintamabTisotumab vedotinZilovertamab vedotinDepatuxizumab MMAE
MoxetumomabSacituzumabDisitamab vedotinPolatuzumab vedotinADC Control Human IgG1-vcMMAF
AzintuxizumabUpifitamabBelantamabPivekimabSacituzumab govitecan (solution)
LifastuzumabGlembatumumabPatritumab deruxtecanFarletuzumab ecteribulin
Payloads and Linker modified Payloads
ExatecanBelotecan HClSGD-1882Dolastatin 10MC-Val-Cit-PAB-Doxorubicin
SN 38GimatecanMMAFCalicheamicinGly3-Val-Cit-PAB-MMAE
AmrubicinTaltobulinAuristatin EEribulin MesylateSuO-Glu-Val-Cit-PAB-MMAE
Mitomycin CDxdChlorambucilSoblidotin (Auristatin PE)Fmoc-G-amino-CH2O acetyl-Exetecan
Deruxtecan analogLurtotecanPF-06380101Deruxtecan analog 2DM1-MCC-PEG3-Biotin
sulfo-SPDB-DM4Exatecan mesylateAuristatin FPaclitaxelGGFG-amino-CH2O-acetyl Exetecan
RubitecanMC-DM1MMAF-methyl esterMC-MMD10Mal-PEG8-Val-Cit-PAB-MMAE
(4-NH2)-ExatecanIrinotecanDoxorubicin-SMCCSPDB-DM4DBCO-PEG4-Val-Cit-PAB MMAF
TopotecanPNU-159682MMAD10-HydroxycamptothecinTopotecan Hydrochloride
CL2A-SN38DM47-Ethylcamptothecin

Cell Biology Reagents
Neuro-DiO, lipophilic tracerVU (5-Vinyl-uridine)CM-DiI, lipophilic tracerLumiTracker ER GreenER-Tracker Red (BODIPY TR Glibenclamide)
Annexin V-AF 647 conjugateDAPI, blue fluorescent nucleic acid stainPropidium IodideDeep-Red Fluorescent Nissl StainMitoCLox, mitochondrial lipid peroxidation probe
Annexin V-AF 488 conjugateLumiTracker Mito Rhodamine 123LumiTracker Mito Green FMRAPID DiI, lipophilic tracerLaurdan (6-Dodecanoyl-2-dimethylaminonaphthalene)
Annexin V, His TagThiazole OrangeSynaptoProbe® RedLumiTracker ER RedLinear Polyacrylamide for Nucleic Acid Precipitation
DiD, lipophilic tracerRH 237, potentiometric probeSynaptoProbe® GreenRAPID DiO, lipophilic tracerFluo-4 AM, green fluorescent calcium indicator
DiR, lipophilic tracerHoechst 33342, blue fluorescent nucleic acid stainLumiTracker® Mito Red FMDiI, lipophilic tracerYODi-1, green fluorescent nucleic acid stain
DNA
CPG solid supportsDNA StainsModified Triphosphatesphosphoramidite
Probes
Biotin PEGFolate PEGImage ProbesPROTAC Linker
Amine reactive Linkers
Acid PEGAldehyde PEGBromo PEGMaleimide PEGNHS ester PEG


AxisPharm提供的服务

● 蛋白质组学服务:提供质谱分析、蛋白质鉴定和定量服务。专注于生物标志物分析,帮助客户在复杂的生物样本中发现和验证潜在的生物标志物。

● 代谢组学服务:利用先进的LC-MS/MS技术进行代谢物分析,提供通路洞察,帮助客户理解代谢途径和生物过程。

● 高级LC-MS/MS服务:用于PK分析和HPLC分离,确保高精度和高效率的研究结果,提供PK/PD研究,支持药物开发和临床前研究。


AxisPharm部分产品列表


Cat#NameM.W.Purity
AP15197Exatecan435.45≥98%
AP15072SN 38392.4≥95%
AP15226Amrubicin483.47≥98%
AP15664Mitomycin C334.3≥98%
AP1520310-Hydroxycamptothecin364.35≥95%
AP152047-Ethylcamptothecin376.41≥95%
AP15210Rubitecan393.35≥95%
AP15211(4-NH2)-Exatecan403.43≥95%
AP15206Topotecan421.5≥95%
AP15207Topotecan Hydrochloride425.5≥95%
AP15202Belotecan HCl433.5≥95%
AP15208Gimatecan447.5≥95%
AP15227Taltobulin473.65≥99%
AP15201Dxd493.48≥95%
AP15209Lurtotecan518.56≥95%
AP15196Exatecan mesylate531.55≥98%
AP15200Deruxtecan analog 2579.58≥95%
AP15205Irinotecan586.68≥95%
AP15224PNU-159682641.62≥98.24%
AP15220Soblidotin (Auristatin PE)701.98≥95%
AP15225SGD-1882725.8≥98%
AP15213MMAF732≥95%
AP15216Auristatin E732≥95%
AP15311Chlorambucil304.21≥98
AP15219PF-06380101743.01≥95%
AP15214Auristatin F746≥95%
AP15215MMAF-methyl ester745.99≥98%
AP15187Doxorubicin-SMCC762.8≥98%
AP15217MMAD771.06≥98%




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荷兰Duchefa Biochemie B.V.公司作为DUCHEFA FARMA BV的基础上成立于1989年,而后者50多年来一直为世界各药厂和医院提供生化试剂以及药物原材料。1989年,身处在农业和花草业方面以及国际贸易有着悠久历史的荷兰,Duchefa公司成立了植物组织及细胞培养实验室,开始向世界提供各种高质量植物组培产品。十多年以来,这些产品已经广泛应用在世界各国一流大学的实验室研究,以及植物细胞组织相关的研发中。在Duchefa公司主要提供植物细胞和组织培养基、各种植物生长调节剂、抗生素、植物胶凝、酶作用底物、植物分子生物化学试剂以及种子病原体检测试剂,种类超过400种的试剂用于植物生物技术开发以及植物病理学研究。

Duchefa Biochemie bv offers a whole range of plant tissue culture media, biochemicals, containers, bioreactors and alot of other products needed for micro-propagation. All media are produced in our own laboratories and custom made media are produced for many customers.

 

主要产品类型:

ENZYMES

GELLING AGENTS

GROWTH REGULATORS

PHYTOPATHOLOGICA & MICROBIOLOGY

PLANT TISSUE CULTURE MEDIA

PTC CONTAINERS

REAGENTS & BIOCHEMICALS

UTENSILIA

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邮箱:sales@amyjet.com

网站:www.amyjet.com

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艾美捷科技代理Bold Biotechnology(BBT)品牌全系列产品


Bold Biotechnology Co., Ltd (简称BBT)是一家综合性健康产业集团,拥有卓越的生命健康技术。BBT致力于研发全球最前沿的领先技术,涵盖以下领域:癌症预防、免疫细胞治疗(BAK、NK、DC免疫疗法)、外泌体研发、血清无免疫细胞用干细胞培养基、超早期癌症筛查、发酵马乳外泌体研发与生产,高浓度维他命C制备等十余项核心生物技术。BBT公司的主要包括细胞培养基相关产品以及免疫化学检测类相关产品。


BBT页面.png


▍BBT公司产品线

αβ-T・γδ-T细胞培养基及配套产品

EALI515-T 无血清培养基:专用于人类及小鼠外周血淋巴细胞的培养。该培养基支持多种淋巴细胞的增殖与活化(包括αβ-T细胞、γδ-T细胞、CTL细胞、NKT细胞及NK细胞),适用于癌症免疫疗法。


ProductDescriptionCodePackageStore at
EALITM515-T (Without IL-2)Originally modified medium based on Iscove’s modified Dulbecco’s Medium (IMDM).
Basal medium for low-serum or serum-free culture of human and mouse Lymphoblast cells.
pH: 7.1-7.6
Osmolarity: 280-300 mOsm/Kg H2O
Membrane filtered, Endotoxin tested, Cell culture teste
15021,000 mL2~10℃


 NK细胞培养基

EALI515-NK 无血清培养基:专用于人类自然杀伤细胞(NK细胞)培养。本培养基支持NK细胞的活化与增殖,适用于癌症免疫疗法。

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ProductDescriptionCodePackageStore at
EALITM515-NK (Without IL-2)Basal medium for low-serum or serum-free culture of human and mouse Lymphoblast & NK cells.
pH: 7.1-7.6
Osmolarity: 280-300 mOsm/Kg H2O
Membrane filtered, Endotoxin tested, Cell culture tested.
16021,000 mL2~10℃
EALITM515-NK (IL-2 700 IU/mL)Recommend for expansion culture of NK cells.
Containing 700 IU/mL of IL-2.
pH: 7.1-7.6
Osmolarity: 280-300 mOsm/Kg H2O
Membrane filtered, Endotoxin tested, Cell culture tested.
16221,000 mL2~10℃
EALITM515-NK (IL-2 1,000 IU/mL)Recommend for early stage culture of NK cells.
Containing 1,000 IU/mL of IL-2.
pH: 7.1-7.6
Osmolarity: 280-300 mOsm/Kg H2O
Membrane filtered, Endotoxin tested, Cell culture tested
16321,000 mL2~10℃


 间充质干细胞(MSCs)无血清/无异源培养基及配套产品

αMSCM 培养基:基于改良型αMEM基础培养基优化开发,支持牙髓、脐带、骨髓及脂肪组织来源间充质干细胞(MSCs)的无异源/低血清培养。

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ProductDescriptionCodePackageStore at
Basal medium (modified αMEM) αMSCM BasalA basal medium without L-Glutamine and Cell Growth Factors (GFs). (containing rh-Transferrin and rh-Insulin).
This product can be used for low serum culture of various MSCs. Add 2mM L-Glutamine, Cell growth Factors and 2% Fetus Bovine Serum (FBS) before use.
Recommend use of x100 3GF Supplement (code: 3151F) as additive.
1801500 mL2~10℃
Xeno-Free culture medium αMSCM+PLThis Product is a set of Xeno-Free medium and human Platelet Lysate (hPL:UltraGro*). No need additional growth supplements, serum and cell adhesion molecule.1811500 mL2~10℃
Cell Growth factor mixture x100 3GF SupplementA mixture of recombinant human FGF-2, PDGF-BB and TGF-β1. Contains recombinant human albumin as a stabilizer.This product is lyophilized.3151F5 mg4~8°C


● 蛋白质生产用化学成分确定培养基

EALI515-MAb 培养基:杂交瘤细胞培养与抗体生产专用培养基,本产品采用无动物源性蛋白配方(不含血清白蛋白),能支持多种杂交瘤细胞的高效增殖并维持抗体生产能力。培养基中仅含胰岛素与转铁蛋白两种蛋白组分,相比含血清或白蛋白的培养基,可显著简化培养上清中单克隆抗体的分离纯化流程。

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ProductDescriptionCodePackageStore at
EALI 515-MAbNewly designed chemically defined medium of Hybridoma cell culture and production of Monoclonal Antibody. Containing hr-Insulin and hr-Transferrin.
Without Serum Albumin or other animal derived proteins.
pH: 7.3-7.7
Osmolarity: 280-300 mOsm/Kg H2O
Membrane filtered, Endotoxin tested, Cell culture tested.
14021,000 mL2~10℃


● 其他细胞培养相关产品


ProductDescriptionCodePackageStore at
Dulbecco’s Phosphate Buffered Saline, “PBS(-)”Dulbecco’s Phosphate–Buffered Saline
pH: 7.3-7.5
Osmolarity: 276-284 mOsm/Kg H2O
Membrane filtered
Endotoxin tested
2101500 mLRoom temp.
Anti CD3 MAb for CIK TactimabTMAffinity purified anti-CD3 monoclonal antibody without preservative.
Manufactured by animal protein free culture of mouse Hybridoma clone OKT3 cell.
Stimulate the growth of human T Lymphocyte in vitro.

Membrane filtered.
Endotoxin tested.
T cell culture tested.
This product is lyophilized.
3121F1 ㎎Freezing
Anti CD3 MAb for CIK TactimabTMAffinity purified anti-CD3 monoclonal antibody without preservative.
Manufactured by animal protein free culture of mouse Hybridoma clone OKT3 cell.
Stimulate the growth of human T Lymphocyte in vitro.

Membrane filtered.
Endotoxin tested.
T cell culture tested.
This product is lyophilized.
3122F10 ㎎Freezing


 免疫化学检测试剂盒与试剂


ProductDescriptionCodePackage
CTX-ELISA 1BPlate Wash Buffer x20 conc, W-181111 x 50 mL
CTX-ELISA 1BSTD/Sample Diluent, D-181121 x 50 mL
CTX-ELISA 1BAnti-CTX1B-ALP Diluent, D-281131 x 50 mL
CTX-ELISA 1BALP Substrate Solution (pNPP), R-181141 x 50 mL
CTX-ELISA 1BELISA Assay Plate CTX1B 81152 x 96 well
CTX-ELISA 1BAnti-CTX1B-ALP:Freeze dry powder81161 tube
CTX-ELISA 1BCTX-1B STD 5 ng/mL81171 x 100 μL
CTX-ELISA 1BAdhesive plastic sheet--6 sheet
CTX-ELISA 1BOperation manual--1
Plate Wash Buffer x20 conc. W-1x20 concentrated Tris-buffer(pH 7.5) with tween 20, blocking reagent and preservative.
20 hold dilute with pure water before use.
811150 mL
STD/Sample Diluent D-1Specially developed buffer solution to dissolve hydrophobic Ciguatoxin molecule into the water.
pH 7.5.Ready to use.
811250 mL
Anti-CTX1B-ALP Diluent D-2Specially designed buffer solution(pH 7.5) for dilution of alkaline-phosphatase conjugated antibody, with Mg++, blocking material and detergent. Ready to use.811350 mL
ALP Substrate Solution (pNPP) R-1Alkaline-phosphatase substrate solution.
Alkaline solution of 0.01% disodium p-Nitrophenylphosphate (pNPP).
pH10,Useful for colorimetric assay of Alkaline-phosphatase. Ready to use.
811450 mL
ELISA Assay Plate CTX1BAnti-CTX1B antibody immobilized 96 well micro-plate.
Protected with blocking reagents to stabilize antibodies.
More than 8 months store is possible under dry conditions of 4 ℃ or less.
81151 plate



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艾美捷科技特约代理Encapsula NanoSciences公司产品。


Encapsula NanoSciences是美国一家致力于提供基于脂质纳米微粒技术(脂质体)的研发和生产的高科技生物纳米技术公司,具有多项知识产权。Encapsula NanoSciences公司现拥有Clodrosome ® , Encapsome ®和Fluoroliposome ® 三个注册商标品牌,提供表面活性脂质体配方和生产服务,包括抗体/多肽交联(Immunosome)、氯磷酸盐脂质体(Clodrosome)及其对照脂质体(Encapsome)、阿霉素脂质体(Doxosome)、DNA和 RNA脂质体 (Genesome)、荧光脂质体(Fluoroliposome)、冻干ATP脂质体(ATPsome)、多款用于人造细胞模型的细胞脂质体(Cellsome)、用于抗肿瘤药物封装的脂质体、多款用于皮肤学及化妆品研发领域的脂质体(Cosmesome) 、以及用于姜黄色素(Curcusome)、肌醇(Inosisome)和宠物专用的营养补充剂脂质体 (Taurosome) 。公司产品服务于学术研究及工业生产等多个领域。通常根据客户需求提供实验室规模的预制脂质体产品。

 

Encapsula NanoSciences is a specialty company focused on providing liposome research, development and manufacturing expertise in the production of lipid-based nanoparticles, also known as liposomes, to clients and partners in both the academic and industrial sectors. Encapsula routinely provides custom laboratory-scale liposome preparations of drug encapsulated liposomes such as Clodrosome® (clodronate liposomes), Encapsome® (plain-control liposomes for clodronate liposomes), Doxosome™ (doxorubicin liposomes), Immunosome™ (reactive liposomes for antibody, protein conjugation), Immunodox™ (reactive liposomes for antibody, protein conjugation containing doxorubicin), Immunogene™ (reactive liposomes for antibody, protein conjugation containing genetic material), Immunofluor™ (reactive liposomes for antibody, protein conjugation containing fluorescent molecules for tracking), Genesome™ (liposomal DNA and RNA), Fluoroliposome™ (fluorescent liposomes), Atpsome™ (ATP liposomes), Cellsome™ (plain liposomes as artificial cell models) and Cosmesome™ (liposomes used in dermatology) to clients in universities and industrial research labs. Encapsula NanoSciences also recently introduced two oral liposomal product lines; NanoLife Nutra for pets and NanoLife Tonics for humans.

 

Encapsula NanoSciences的主要产品包括:

Plain Liposomes as Artificial Cell Models or as Control

Small Molecules Encapsulated into Liposomes

Magnetic Liposomes

Fluorescent Liposomes

Spin labeled Liposomes

Encapsulation of Genetic Materials into the Liposomes

Liposomes used for Electro-Injection

Long-Circulating Sterically Protected Liposomes

Surface Modification of Liposomes

pH Sensitive Liposomes (PSL)

Freeze-Dried Liposomal Systems

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艾美捷科技有限公司

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邮箱:sales@amyjet.com

网站:www.amyjet.com

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艾美捷科技代理Purepeg品牌全系列产品


PurePEG, LLC是一家致力于为学术和商业用户提供高质量、高纯度单分散聚乙二醇(PEG)及其相关产品的领先供应商,提供具有不同重复单元(间隔基长度)、末端官能团(X 和 Y)以及多种分子结构(线性、支化和多臂型)的产品。PurePEG 凭借多年研发积累的创新 PurePEG 技术,能够生产具有精确分子量的纯净、单分散 PEG。PurePEG 开发了首个用于偶联抗体与毒素(ADC药物)以治疗乳腺癌的酸功能化PEG。PEG因其水溶性、无毒性和非免疫原性等特性,已在生物医学领域确立了重要地位。迄今为止,已有 12 种经 FDA 批准的聚乙二醇化药物用于治疗多种慢性疾病。此外,PurePEG提供从毫克级到公吨级多种PEG产品的高质量定制合成与合同研发服务。


Purepeg页面.png


▍Purepeg产品线


PurePEG提供以下相关目录产品:


Diselenide LinkersClickable LinkersPEG45Linker with protecting group
Peptide LinkersBCN LinkerPEG-LipidBiotinylation Reagents
Polydisperse PEGBCN linker (non PEG)PEGylation ReagentsMulti-Arm PEGs
PROTACDiazirine LinkerHeterobifunctional PEGsCleavable Linkers
Chelating AgentPorphyrinHomobifunctional PEGsNon-PEG Linkers


▍Purepeg部分产品列表


品名货号CAS号分子式分子量
3,3′-Diselenobispropionic acid5123717370-58-3C6H10O4Se2304.06
di-tert-butyl 3,3′-diselanediyldipropionate512282N/AC14H26O4Se2416.3
2,2′-diselanediyldiacetic acid51236116066-50-5C4H6O4Se2276.01
di-tert-butyl 2,2′-diselanediyldiacetate512281N/AC12H22O4Se2389.98
Azido-PEG4-Val-Ala-PAB-PNP5126604N/AC33H45N7O12731.8
Azido-PEG4-Val-Ala-PAB5116604N/AC26H42N6O8566.7
Mal-amide-PEG6-Val-Cit-PAB-OH5162063034751-42-0C40H63N7O14865.4
Mal-PEG8-amide-Val-Ala-Exatecan5116208N/AC58H78FN7O181179.539
MC-Val-Cit-PAB-PNP51057159857-81-5C35H43N7O11737.8
MC-Val-Ala-PAB-OH510561870916-87-2C25H34N4O6486.56
MC (C5)-Val-Cit510552504147-59-3C20H31N5O7453.5
SPDP-Val-Cit-PAB-PNP51054N/AC33H39N7O9S2741.8
SPDP-Val-Cit-PAB-OH51053N/AC26H36N6O5S2576.7
Alloc-Val-Ala-PAB510511343407-91-9C19H27N3O5377.4
DBCO-PEG4-Val-Ala-PAB51148042348405-92-3C45H57N5O10827.9
Boc-PEG2-Val-Cit-PAB-OH5127022055024-55-8C30H50N6O9638.75
endo BCN-PEG3-VC-PFP Ester51963032353409-45-5C37H50F5N5O10819.8
endo BCN-PEG3-Val-Cit511203N/AC31H51N5O10653.8
Azido-PEG3-Val-Cit-PAB-PNP5166032055047-18-0C34H47N9O12773.8
Azido-PEG4-Val-Cit-PAB-OH5166042055024-64-9C29H48N8O9652.8
Boc-PEG4-Val-Cit-PAB-OH5127042055024-54-7C34H58N6O11726.86
Boc-PEG6-Val-Cit-PAB-OH5127062055024-53-6C38H66N6O13814.96
6-Azidohexanoyl-Val-Cit-PAB510471613321-01-9C24H38N8O5518.61
DBCO-PEG4-Val-Cit-PAB-PNP5148042226472-28-0C55H66N8O151079.2



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传真:18771997407

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